Photo: Body on a Chip (BoC)-BoC technology uses microfluidic systems and advanced tissue engineering techniques to create a system that mimics the complexity and interactions of different human organs and tissues. BoC has the potential to revolutionize the field of medicine by providing more accurate and efficient methods for drug development, disease modeling and personalized medicine.

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Two-organ chip to answer fatty liver questions

A new chip that holds different cell types in tiny, interconnected chambers could allow scientists to better understand the physiological and disease interactions between organs. The integrated-gut-liver-on-a-chip (iGLC) platform was designed by scientists at Kyoto University, to improve understanding of non-alcoholic fatty liver disease (NAFLD). The researchers, together with colleagues in Japan, published their findings in the journal Communications Biology. (More)

Publication information: Communications Biology |DOI: 10.1038/s42003-023-04710-8
“Integrated gut–liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease”
Authers：Jiandong Yang, Yoshikazu Hirai, Kei Iida, Shinji Ito, Marika Trumm, Shiho Terada, Risako Sakai, Toshiyuki Tsuchiya, Osamu Tabata, and Ken-ichiro Kamei

Research highlight

Enhancing realism of gut-liver axis model: Organ-on-chip device allows separate flows for gut and liver cells, producing a more realistic model of gut and liver interactions in humans that could be used to study related diseases and their treatments. (See AIP Scilight: https://doi.org/10.1063/10.0013986)

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